Lymphoma (Lymph Node Cancer)

What is Lymphoma?

Lymphoma occurs when lymphocytes begin to divide uncontrollably and collect in lymph nodes or other organs. The disease is mainly divided into two main groups: Hodgkin lymphoma and non-Hodgkin lymphoma (the most common form). The disease can be either aggressive (fast-growing) or indolent (slow-growing). Since lymphocytes circulate in the blood and lymph, lymphoma is often regarded as a systemic disease affecting the entire body.

Causes and Risk Factors

Why some individuals are affected is not fully understood, but research indicates it often involves damage to cellular DNA occurring later in life.

• Age: The risk for most types of lymphoma increases with age, though some forms primarily affect younger people.
• Weakened Immune System: People with autoimmune diseases or those taking immunosuppressant medications have a slightly increased risk.
• Infections: Certain viruses, such as Epstein-Barr (glandular fever) or the bacterium Helicobacter pylori, can be linked to specific types of lymphoma.
• Environmental Factors: Exposure to certain chemicals and pesticides has been discussed as possible risk factors.

Common Symptoms of Lymphoma

Symptoms of lymphoma are often vague, develop gradually, and can easily be confused with other less serious conditions like common infections. It is therefore important to be attentive to the body's signals.

The most common signs to watch for:

• Enlarged or Swollen Lymph Nodes: Often in the neck, armpits, or groin. They are usually firm and typically painless.
• Fatigue: Persistent exhaustion that cannot be rested away.
• Fever and Night Sweats: Fever without an obvious cause and heavy sweating during the night.
• Unintentional Weight Loss and Loss of Appetite: Losing weight without changes in diet or exercise habits.

If you experience general concern or vague symptoms, a broad blood analysis can be a valuable first step to see if the body's levels deviate:

Health Check Large : Includes blood status (to see levels of white blood cells and hemoglobin) and CRP, which are often elevated during inflammatory processes or lymphoma.

Leukocytes (White Blood Cells) : A specific check of the cells involved in lymphoma.

Differential Leukocyte Count : This test provides a detailed picture of the different types of white blood cells. In lymphoma, it is particularly important to see if the number of lymphocytes is abnormally high or low, or if there are immature cells in the blood that should normally only exist in the bone marrow.

Treatment and Prognosis

The prognosis for lymphoma has improved dramatically in recent decades. Many forms are now fully curable, while chronic forms can often be managed over long periods, allowing patients to live a good life.

• Chemotherapy: The most common form of treatment.
• Immunotherapy: Targeted antibodies that help the body's own immune system attack cancer cells.
• Radiation Therapy: Often used as a supplement if the disease is localized to a specific area.
• Stem Cell Transplantation: May be relevant in cases of relapse or particularly hard-to-treat forms.

Important: Swollen lymph nodes are usually due to common infections like colds. However, if a node is larger than 1 cm, is hard, and does not recede within 3–4 weeks, you should always seek medical attention for an assessment.