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IgE Total – Supplementary blood test for allergy testing
IgE, or immunoglobulin E, is an antibody produced by the immune system. It is part of the body's defenses but is also closely linked to allergic reactions. IgE antibodies are secreted by immune cells when the body is exposed to foreign substances, so-called allergens. These antibodies can trigger the release of substances such as histamine, which can lead to symptoms such as itching, runny nose and hives.
Measuring total IgE provides an indication of the body's allergic tendency. The analysis is performed on serum, which is the fluid that remains after the blood has been allowed to clot and all blood cells have been removed.
Why test IgE Total?
The analysis of total IgE is used as part of allergy testing, but can also be relevant when investigating parasitic diseases and immunodeficiency states. Elevated levels may indicate that the immune system is affected, but a normal level does not rule out allergic disorders.
Elevated concentrations of total IgE can be seen in:
- Allergic reactions such as pollen, fur animal and food allergies
- Parasitic infections
- Certain autoimmune diseases
- Immunodeficiency diseases
- Certain types of cancer such as B-cell lymphoma and chronic lymphocytic leukemia
- Smoking and certain viral infections
Can elevated IgE levels have causes other than allergy?
Yes, elevated levels can also occur in parasitic diseases, immunodeficiency states, autoimmune diseases as well as in smoking and certain infections. Note that low concentrations of IgE do not rule out allergy, as specific IgE antibodies to individual allergens may be present despite normal total IgE levels. IgE levels peak a few weeks after exposure to an allergen and then gradually decline.
Interpretation of S- IgE (Immunoglobulin E) test results
- A normal IgE value reduces the likelihood of allergy, but does not completely rule it out.
- An elevated IgE value may indicate an allergic reaction or an atopic condition, but it may also be due to other conditions such as parasitic infections or immunodeficiency. If necessary, specific IgE tests can be used to investigate which allergens trigger the reaction.
