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HTC

Holotranscobalamin

Holotranscobalamin, often abbreviated HTC, is the active form of vitamin B12 – the fraction that can be absorbed by the body’s cells. A holotranscobalamin test is used to detect early signs of B12 deficiency and to assess the body’s nutritional status.

HTC

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Contents

What is holotranscobalamin?

Holotranscobalamin (HTC) is a specific fraction of vitamin B12 that is bound to a transport protein called transcobalamin II. With the help of this protein, the body’s cells can absorb and use the vitamin where it is needed. Only about 10–30% of all B12 in the blood exists as HTC, but it is this portion that the body can actually utilize.

The role of vitamin B12 in the body

Vitamin B12 is essential for the production of red blood cells, proper nerve function, and DNA synthesis. Low levels of B12 can lead to anemia, neurological problems, and reduced energy metabolism.

Identifying B12 deficiency using holotranscobalamin

HTC is considered a more sensitive marker than total B12 because it reflects the amount of active vitamin available in the blood. HTC levels often decrease before total B12 is affected, allowing for earlier detection of deficiency.

How is holotranscobalamin measured?

HTC levels can be measured through a blood test . The result is often interpreted together with other markers such as total B12 , Methylmalonate (MMA) and Homocysteine to provide a more complete picture of vitamin status. Low HTC combined with elevated MMA confirms a deficiency of active B12 (HTC).

What can cause low holotranscobalamin levels?

Low holotranscobalamin levels are often an early sign of vitamin B12 deficiency. B12 deficiency is commonly caused by poor absorption, a vegetarian or vegan diet, atrophic gastritis, or autoimmune disease (pernicious anemia), and may lead to anemia and, in severe cases, neurological damage.

Symptoms of vitamin B12 deficiency

Low levels of active vitamin B12 can affect several body functions – particularly blood formation and the nervous system. The symptoms often develop gradually and can vary in severity. Here are some common signs that may indicate a B12 deficiency:

  • Fatigue and general weakness
  • Pale skin and shortness of breath
  • Tingling or numbness in hands and feet
  • Dizziness or impaired balance
  • Poor memory, concentration difficulties, and mental fatigue
  • Low mood or depression
  • Sore or inflamed tongue (glossitis) and mouth ulcers
  • Digestive issues such as nausea, loss of appetite, or diarrhea

Tests containing the marker Holotranscobalamin

Health checks

Health checks

Health check B12 deficiency

Health check B12 deficiency

Investigation of B12 deficiency
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Medical comment included

With us, you will always receive a doctor’s opinion from a licensed physician when you order a medical check-up that includes a medical opinion. The doctor’s opinion includes an overall assessment of your results from laboratory analysis. The opinion is individual and may vary depending on the specific tests your medical check-up includes.

What can I expect in the medical report?

The medical opinion will summarize the results of your test results to give you an assessment of your health including any abnormalities outside the reference ranges. In case of abnormalities or need, your doctor may also contact you for a free conversation to explain and talk about your results. Remember that a health check always includes specific test results based on your health and your personal circumstances. Values outside the reference range should therefore always be discussed with a doctor before any decisions regarding possible treatment are made.

What does the doctor look at during a health check?

When assessing a blood test or health check, your doctor will look at several different parameters to evaluate your health and identify any abnormalities. Below are some common aspects your doctor may examine:

Blood counts: Your doctor will check red, white and platelet counts to identify any signs of anaemia, infection or bleeding.

Nutrients and biochemical markers: Includes, for example, analysis and monitoring of blood sugar (glucose) levels, electrolyte levels (e.g. sodium, potassium), liver function tests (e.g. liver enzymes), kidney function tests (e.g. creatinine, urea) and lipid profile (e.g. cholesterol, triglycerides). The results of the tests give your doctor a better idea of your organ function, blood sugar level, cholesterol conditions and other important health aspects.

Inflammatory markers: Your doctor may measure health markers such as C-reactive protein (CRP) or red blood cell decrease rate (SR) to evaluate inflammatory conditions or confirm an active infection.

Hormone levels: Your doctor may monitor your hormone levels to assess hormonal imbalances or diseases, such as thyroid hormones (TSH, T3, T4), sex hormones or other specific hormones such as testosterone levels.

Specific tests: Depending on your goal of your health check or medical history, your doctor may look into specific tests to investigate conditions or diseases, such as diabetes, vitamin deficiency or autoimmune diseases.

In conclusion, the doctor weighs all test results based on the health check to assess your overall health, detect any abnormalities and identify possible underlying medical conditions.

What happens if I have abnormal test results?

If your blood count is abnormal, this will be addressed in your personal medical opinion. Depending on the nature and extent of the abnormality, your doctor may also contact you directly through the test result service for further guidance. Various measures and advice will be provided based on the specific abnormalities observed along with your medical history.

  • Blood analysis for investigation of suspected B12 deficiency.
  • In-depth analysis to identify functional B12 deficiency.
  • Assessment of blood count and impact on red blood cells.
  • Recommendations for action and follow-up.

1 195 kr

Vitamin tests

Vitamin tests

HTC

S-Holotranscobalamin

Active B12
Marker Icon 1 marker
  • Measures active vitamin B12
  • Detects B12 deficiency earlier than total B12
  • Used in the investigation of anemia, neurological or psychological symptoms
  • Suitable for risk groups such as the elderly, vegans, and people with impaired absorption

    • 279 kr

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