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MMA

Methylmalonic acid

Methyl Malonate (MMA)

Methyl malonate (MMA) is a substance in the body that helps break down certain fats and proteins. It is part of a process called the Krebs cycle, which is important for the body to be able to produce energy. An analysis of MMA is often used to investigate whether there is a deficiency of vitamin B12. The MMA concentration in the blood increases when there is not enough B12.

MMA

Methyl malonate

Methylmalonic Acid Test

649 kr

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Contents

What is Methyl Malonate MMA?

Methyl malonate also known as MMA is a metabolite that has an impact on the body's metabolism. MMA works in the breakdown of specific fatty acids and amino acids. To produce this energy, the body uses a process called the Krebs cycle, which can be more simply explained as an assembly line in a factory where energy is produced. Methyl malonate is a part that needs to be processed on this assembly line. Because Vitamin B12 is necessary to convert MMA into another important part, called "succinyl-CoA" which is essential for the energy-producing process to work efficiently. In the case of a lack of vitamin B12, the process is disturbed, which can cause a lack of energy in the body.

Since MMA levels are dependent on the availability of vitamin B12, a blood test for MMA can be performed to identify mild forms of B12 deficiency. When there is a deficiency of this B12, the body cannot efficiently convert MMA, resulting in a gradual increase of MMA in the blood. Therefore, analysis of MMA is a relevant diagnostic method that can possibly confirm vitamin B12 deficiency in people whose B12 levels are in the borderline range or when symptoms are ambiguous.

Why is MMA analyzed?

Analysis of MMA is recommended when B12 deficiency is suspected where B12 levels are low but within reference and when symptoms of B12 deficiency occur at the same time. Common symptoms include fatigue, weakness, nerve damage and cognitive impairment, these can be mild and even overlap with other medical conditions. An elevated MMA value therefore provides support for the diagnosis of B12 deficiency, which can facilitate decisions for treatment in order to prevent potentially irreversible damage. This makes MMA analysis a valuable tool in both clinical diagnostics and monitoring the effectiveness of treatment.

What does a high value of MMA mean?

A high value of methylmalonate (MMA) in the blood can be an indication that there is a lack of vitamin B12 in the body.

What does a low value of MMA mean?

A low value of methylmalonate (MMA) in the blood or urine is usually a sign that the body has sufficient amounts of vitamin B12 to efficiently convert MMA into succinyl-CoA, part of the body's energy production system. Low MMA levels are normally considered a sign of good health and that the metabolic processes involving vitamin B12 are working properly.

Reference interval MMA and interpretation of test results

When interpreting test results of MMA, it is important to understand that elevated levels often indicate a lack of vitamin B12, so-called "cobalamin deficiency". If an elevated MMA value is caused by B12 deficiency, it usually tends to normalize quickly after treatment with B12 injections. However, if the person suffers from impaired kidney function, the MMA value may not completely return to normal, but it should at least show a clear decrease relatively quickly.

Reference values MMA

<50 years <0.28 µmol/L

>50 years <0.36 µmol/L

Marginally elevated MMA values should be evaluated with caution, especially if they are observed in elderly individuals or people with kidney problems. These results may require further evaluation to properly diagnose the cause of the elevation and determine the most appropriate treatment.

Tests containing the marker Methyl Malonate (MMA)

Health checks

Health checks

Health check B12 deficiency

Health check B12 deficiency

Investigation of B12 deficiency
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Medical comment included

With us, you will always receive a doctor’s opinion from a licensed physician when you order a medical check-up that includes a medical opinion. The doctor’s opinion includes an overall assessment of your results from laboratory analysis. The opinion is individual and may vary depending on the specific tests your medical check-up includes.

What can I expect in the medical report?

The medical opinion will summarize the results of your test results to give you an assessment of your health including any abnormalities outside the reference ranges. In case of abnormalities or need, your doctor may also contact you for a free conversation to explain and talk about your results. Remember that a health check always includes specific test results based on your health and your personal circumstances. Values outside the reference range should therefore always be discussed with a doctor before any decisions regarding possible treatment are made.

What does the doctor look at during a health check?

When assessing a blood test or health check, your doctor will look at several different parameters to evaluate your health and identify any abnormalities. Below are some common aspects your doctor may examine:

Blood counts: Your doctor will check red, white and platelet counts to identify any signs of anaemia, infection or bleeding.

Nutrients and biochemical markers: Includes, for example, analysis and monitoring of blood sugar (glucose) levels, electrolyte levels (e.g. sodium, potassium), liver function tests (e.g. liver enzymes), kidney function tests (e.g. creatinine, urea) and lipid profile (e.g. cholesterol, triglycerides). The results of the tests give your doctor a better idea of your organ function, blood sugar level, cholesterol conditions and other important health aspects.

Inflammatory markers: Your doctor may measure health markers such as C-reactive protein (CRP) or red blood cell decrease rate (SR) to evaluate inflammatory conditions or confirm an active infection.

Hormone levels: Your doctor may monitor your hormone levels to assess hormonal imbalances or diseases, such as thyroid hormones (TSH, T3, T4), sex hormones or other specific hormones such as testosterone levels.

Specific tests: Depending on your goal of your health check or medical history, your doctor may look into specific tests to investigate conditions or diseases, such as diabetes, vitamin deficiency or autoimmune diseases.

In conclusion, the doctor weighs all test results based on the health check to assess your overall health, detect any abnormalities and identify possible underlying medical conditions.

What happens if I have abnormal test results?

If your blood count is abnormal, this will be addressed in your personal medical opinion. Depending on the nature and extent of the abnormality, your doctor may also contact you directly through the test result service for further guidance. Various measures and advice will be provided based on the specific abnormalities observed along with your medical history.

  • Blood analysis for investigation of suspected B12 deficiency.
  • In-depth analysis to identify functional B12 deficiency.
  • Assessment of blood count and impact on red blood cells.
  • Recommendations for action and follow-up.

1 195 kr

Other health tests

Other health tests

MMA

Methyl malonate

Methylmalonic Acid Test
Marker Icon 1 marker
  • Measures the MMA concentration in the blood.
  • Analysis of methyl malonate.
  • When investigating Vitamin B12 deficiency.

649 kr

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